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A new biflavonyloxymethane from Pongamia pinnata. The root bark of Pongamia pinnata Pierre Syn Pongamia glabra Family: Fabaceae has afforded a new biflavonyloxymethane, karanjabiflavone, along with a known furanoflavone, pongapin. The structure of this new biflavonyloxymethane was elucidated from extensive spectral studies including 2D-NMR experiments.

Both of these compounds possess antioxidant activity. Compound 6 was isolated for first time from the plant of the genus Pongamia.

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Identification of pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits. To identify pongamol and karanjin as lead compounds with antihyperglycemic activity from Pongamia pinnata fruits.

In streptozotocin-induced diabetic rats, single dose treatment of pongamol and karanjin lowered the blood glucose level by Biofibres from biofuel industrial byproduct- Pongamia pinnata seed hull. Biodiesel production using Pongamia pinnata P. These seed hulls serve as a potential source for cellulose fibres which can be exploited as reinforcement in composites. These seed hulls were processed using chlorination and alkaline extraction process in order to isolate cellulose fibres.

The sequential chlorination and alkaline treatment stemmed to the isolation of cellulose fibres from P. The isolated cellulose fibres possessed enhanced morphological, thermal, and crystalline properties in comparison with P.

These cellulose microfibres may potentially find application as biofillers in biodegradable composites by augmenting their properties. Structure and biological activity of a new rotenoid from Pongamia pinnata. Pongarotene 1a new rotenoid and karanjin 2a known flavonol, were isolated from the seeds of Pongamia pinnata.

The structure determination of these compounds were based on spectral analyses including 2D-NMR. The antifungal, antibacterial and phytotoxicity of pure compounds 1 and 2 as well as of the methanol M and ethyl acetate E crude extracts are also being reported. A new chalcone from Pongamia pinnata and its antioxidant properties. The root bark of Pongamia pinnata Pierre [syn P. Karanjapin and karanjachromene were found to possess ificant antioxidant activity. This may play an important role in the pathogenesis of several diseases.

A rapid, simple and specific reversed-phase HPLC method has been developed for analysis of karanjin in Pongamia pinnata Linn. HPLC analysis was performed on a C 18 column using an UV detection was at nm. The method was validated for accuracy, precision, linearity, specificity. Validation revealed the method is specific, accurate, precise, reliable and reproducible. Limit of detection was 4. Intra and inter-day RSD of retention times and peak areas was less than 1.

The established HPLC method is appropriate enabling efficient quantitative analysis of karanjin in Pongamia pinnata leaves. PubMed Central.

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HPLC analysis was performed on a C18 column using an The objective of the current study was to assess the in vitro antiplasmodial activities of leaf, bark, flower, and the root of Pongamia pinnata against chloroquine-sensitive Plasmodium falciparum 3D7 straincytotoxicity against Brine shrimp larvae and THP-1 cell line.

For in vivo study, the plant extract which has shown potent in vitro antimalarial activity was tested against Plasmodium berghei ANKA strain. Sequentially crude extracts of methanol polarchloroform non-polarhexane non-polarethyl acetate non-polar and aqueous polar of dried leaves, bark, flowers and roots of Pongamia pinnata were prepared using Soxhlet apparatus.

The extracts were screened for in vitro antimalarial activity against P. The cytotoxicity studies of crude extracts were conducted against Brine shrimp larvae and THP-1 cell line. Phytochemical analysis of the plant extracts was carried out by following the standard methods. The chemical injury to erythrocytes due to the plant extracts was checked. The in vivo study was conducted on P. Out of all the tested extracts, the methanol extract of the bark of Pongamia pinnata had shown an IC 50 value of The injury to erythrocytes analysis had not shown any morphological alterations and damage to the erythrocytes after 48 h of incubation.

Because methanolic bark extract of Pongamia pinnata has shown good antimalarial activity in vitro, it was also tested in vivo. So the extract had exhibited an excellent activity against P. Growing patterns of pediculocidal drug resistance towards head louse laid the foundation for research in exploring novel anti-lice agents from medicinal plants. In the present study, various extracts of Pongamia pinnata leaves were tested against the head louse Pediculus humanus capitis.

A filter paper diffusion method was conducted for determining the potential pediculocidal and ovicidal activity of chloroform, petroleum ether, methanol, and water extracts of P. The findings revealed that petroleum ether extracts possess excellent anti-lice activity with values ranging between The chloroform and methanol extracts were also successful in inhibiting nymph emergence and the petroleum ether extract was the most effective with a complete inhibition of emergence.

Water extract was devoid of both pediculocidal and ovicidal activities. These showed the prospect of using P. Amongst these isolates, Pseudomonas aeruginosa RRALC3 exhibited the maximum ammonia production and hence was selected for further studies. RRALC3 was found to possess multiple plant growth promoting traits such as nitrogen accumulation Absence of virulence genes and non-hemolytic activity indicated that RRALC3 is unlikely to be a human pathogen.

When the effects of RRALC3 on promotion of plant growth was tested in Pongamia pinnatait was observed that in Pongamia seedlings treated with a combination of RRALC3 and chemical fertilizer, the dry matter increased by Nitrogen, phosphorus and potassium uptake increased by ificant enhancement of total sugar, amino acids and organic acids content, by From the logistic equation, the rapid C accumulation time of Pongamia was computed as 43 days longer than the control when a combination of native PGPB and inorganic fertilizer was applied.

The rapid accumulation time of N, P and K in Pongamia when treated with the same combination as above was 15, 40 and 33 days longer. Microwave assisted alkali-catalyzed transesterification of Pongamia pinnata seed oil for biodiesel production. In this study, microwave assisted transesterification of Pongamia pinnata seed oil was carried out for the production of biodiesel. The experiments were carried out using methanol and two alkali catalysts i. The effect of catalyst concentration and reaction time on the yield and quality of biodiesel was studied. The result of the study suggested that 0.

There was a ificant reduction in reaction time for microwave induced transesterification as compared to conventional heating. All rights reserved.

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Kazakoff, Stephen H. Pongamia pinnata syn. Millettia pinnata is a novel, fast-growing arboreal legume that bears prolific quantities of oil-rich seeds suitable for the production of biodiesel and aviation biofuel.

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It contains a 50 kb inversion common to other legumes, as well as a novel 6. Additionally, two copies of an inverted repeat firmly place the species outside the subclade of the Fabaceae lacking the inverted repeat. The Pongamia and L. Through comparative analysis with Vigna radiata we measured the average synonymous and non-synonymous divergence of all three legume mitochondrial 1.

Finally, we explored the relatedness of Pongamia within the Fabaceae and showed the utility of the organellar genome sequences by mapping transcriptomic data to identify up- and down-regulated stress-responsive gene candidates and confirm in silico predicted RNA editing sites. Capturing the biofuel wellhead and powerhouse: the chloroplast and mitochondrial genomes of the leguminous feedstock tree Pongamia pinnata.

Pongamia pinnata inoculated with Bradyrhizobium liaoningense PZHK1 shows potential for phytoremediation of mine tailings. Mine tailings contain high concentrations of metal contaminants and only little nutrients, making the tailings barren for decades after the mining has been terminated. Effective phytoremediation of mine tailings calls for deep-rooted, metal accumulating, and soil fertility increasing plants with tolerance against harsh environmental conditions.

We assessed the potential of the biofuel leguminous tree Pongamia pinnata inoculated with plant growth promoting rhizobia to remediate iron-vanadium-titanium oxide V-Ti magnetite mine tailing soil by pot experiment and in situ remediation test. A metal tolerant rhizobia strain PZHK1 was isolated from the tailing soil and identified as Bradyrhizobium liaoningense by phylogenetic analysis.

Furthermore, inoculation increased the metal accumulation capacity and superoxide dismutase activity of P. The concentrations of Ni accumulated by inoculated plants were higher than the hyperaccumulator threshold. Inoculated P. In summary, P. Evaluation of wound healing, anti-microbial and antioxidant potential of Pongamia pinnata in wistar rats. To investigate wound healing, antimicrobial and antioxidant activity of leaf extract of Pongamia Pinnata.

Methanolic extracts of P. Antimicrobial activity against ten microorganisms was also assessed. In vivo antioxidant activity was performed to understand the mechanism of wound healing potency. The indicated that P. Hydroxyproline and hexosamine expression were also well correlated with the healing pattern observed.

Increased wound contraction and tensile strength, augmented hydroxyproline and hexosamine content, antioxidative activity and moderate antimicrobial activity support the early wound healing exhibited by P. Induction in cytokine production may be one of the mechanisms in accelerating the wound healing. suggest that P. Antidiabetic activity of Pongamia pinnata leaf extracts in alloxan-induced diabetic rats. The antidiabetic activity of Pongamia pinnata Family: Leguminosae leaf extracts was investigated in alloxan-induced diabetic albino rats. A comparison was made between the action of different extracts of P.

An oral glucose tolerance test OGTT was also performed in experimental diabetic rats. The petroleum ether, chloroform, alcohol and aqueous extracts of P. Pongamia pinnata L. Fabaceae is a promising biofuel tree species which is underexploited in the areas of both fundamental and applied research, due to the lack of information either on transcriptome or genomic data. To investigate the possible metabolic pathways, we performed whole transcriptome analysis of Pongamia through Illumina NextSeq platform and generated 2.

The de novo assembly of raw re generated 40, contigs and 35, transcripts, representing leaf, flower and seed unigenes. Four prominent stages of seed development were selected in a high yielding Pongamia accession TOIL 1 to follow the temporal expression patterns of key fatty acid biosynthetic genes involved in lipid biosynthesis and accumulation. Our provide insights into an array of molecular events from flowering to seed maturity in Pongamia which will provide substantial basis for modulation of fatty acid composition and enhancing oil yields which should serve as a potential feedstock for biofuel production.

Anti-inflammatory Flavanones and Flavanols from the Roots of Pongamia pinnata. A phytochemical study of the roots of Pongamia pinnata afforded 29 flavanones and flavanols, including 7 ly undescribed compounds. The structures of the isolated compounds were determined by 1D and 2D NMR and mass spectroscopy data.

The absolute configurations of the compounds were ased via analysis of the specific rotations and electronic circular dichroism spectra, application of Mosher's method, and by comparing the calculated and experimental electronic circular dichroism spectra. The isolates were evaluated for their inhibitory effects on nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells. All of the isolated compounds exhibited inhibitory effects against nitric oxide production, and most of them showed obvious anti-inflammatory activities IC 50 Studies on Pongamia pinnata L.

Crude decoction of dried leaves of Pongamia pinnata was evaluated for its antimicrobial antibacterial, antigiardial and antirotaviral effect; and its effect on production and action of enterotoxins cholera toxin, CT; Escherichia coli labile toxin, LT; and E. The decoction had no antibacterial, antigiardial and antirotaviral activity, but reduced production of CT and bacterial invasion to epithelial cells.

The observed indicated that the crude decoction of P. Medicinal uses, phytochemistry and pharmacology of Pongamia pinnata L. Pierre: a review. Pierre is one of the many plants with diverse medicinal properties where all its parts have been used as traditional medicine in the treatment and prevention of several kinds of ailments in many countries such as for treatment of piles, skin diseases, and wounds. This review discusses the current knowledge of traditional uses, phytochemistry, biological activities, and toxicity of this species in order to reveal its therapeutic and gaps requiring future research opportunities.

This review is based on literature study on scientific journals and books from library and electronic sources such as ScienceDirect, PubMed, ACS, etc. Several different classes of flavonoid derivatives, such as flavones, flavans, and chalcones, and several types of compounds including terpenes, steroid, and fatty acids have been isolated from all parts of this plant. The pharmacological studies revealed that various types of preparations, extracts, and single compounds of this species exhibited a broad spectrum of biological activities such as antioxidant, antimicrobial, anti-inflammatory, and anti-diabetic activities.

The of several toxicity studies indicated that extracts and single compounds isolated from this species did not show any ificant toxicity and did not cause abnormality on some rats' organs. Thus, this plant has a potential to be used as an effective therapeutic remedy due to its low toxicity towards mammalian cells. However, further study on chemical constituents and their mechanisms in exhibiting certain biological activities are needed to understand the full phytochemical profile and the complex pharmacological effects of this plant.

In addition, further study on the toxicity of the other compounds isolated from this plant required to be assessed to ensure their eligibility to be used as sources of drugs. Anti-Alzheimer activity of isolated karanjin from Pongamia pinnata L.

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